Fast Facts About Restless Leg Syndrome (RLS)

RLS affects 7–10% of the U.S. population, though many cases go undiagnosed. Women are more likely to experience it than men.

RLS is a neurological disorder that causes uncomfortable sensations in the legs, usually described as crawling, tingling, pulling, or throbbing — especially at night.

People with RLS often experience chronic insomnia, leading to brain fog, irritability, anxiety, and daytime fatigue. It's also associated with periodic limb movements during sleep (PLMS), which can disrupt deep sleep cycles.

Emerging research shows a connection between gut health and dopamine regulation — both of which play a role in RLS. Autoimmune conditions, food sensitivities, and even past antibiotic use may all be root triggers.

Low brain iron levels can interfere with dopamine signaling, which is crucial for controlling movement. Many RLS patients have low ferritin, even if their basic labs look "normal."

Certain drugs — like antihistamines, antidepressants, and even anti-nausea meds — can worsen RLS symptoms. And long-term use of dopamine agonists like Ropinirole may cause augmentation, where symptoms come on earlier and more intensely.

While it's called Restless Leg Syndrome, symptoms can also hit during the day — especially during periods of rest or inactivity (like sitting on a plane or watching a movie).

What works for one person may not work for another. That's why personalized, root-cause support is key.